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カタログ番号 | 製品名 | 別名 | ターゲット |
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T27841 | Lobeglitazone Sulfate | CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang | NOD |
Lobeglitazone Sulfate(CKD-501 Sulfate) is a novel thiazolidinedione with anti-inflammatory activity that inhibits LPS-induced NLRP3 inflammasome activation and hepatic inflammation, and can be used in the study of type 2... | |||
T61392 | NLRP3-IN-10 | ZVN26391 | NOD |
NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1β release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome. | |||
T3701 | MCC950 | CP-456773 | NOD |
T60442 | NLRP3/AIM2-IN-3 | NOD , AIM2 | |
NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of N... | |||
T78894 | NLRP3-IN-21 | NOD-like Receptor (NLR) | |
NLRP3-IN-21 (compound L38) is an inhibitor of the NLRP3 inflammasome that possesses anti-inflammatory properties. It suppresses the activation of the NLRP3 inflammasome and pyroptosis by inhibiting gasdermin D cleavage, ... | |||
T10447 | BAA473 | Others | |
BAA473 is a bile acid analog that is a potent activator of the pyrin inflammasome. BAA473 can induce secretion of interleukin-18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial c... | |||
T68225 | Fc 11a-2 | ||
Fc 11a-2, a benzimidazole compound, functions as an orally active, potent inhibitor of the NLRP3 inflammasome. It effectively hinders the NLRP3 inflammasome formation by blocking caspase-1 activation and consequently the... | |||
T71651 | GSK1370319A | ||
GSK1370319A is a potent P2X7 antagonist (IC50 = 3.2 nM). GSK1370319A inhibits ATP-induced increase in IL-1β release and caspase 1 activation in lipopolysaccharide (LPS)-primed mixed glia by blocking assembly of the infla... | |||
T81665 | NLRP3-IN-23 | NOD-like Receptor (NLR) | |
NLRP3-IN-23 (Compound 15C) is an inhibitor that significantly impedes heme-mediated activation of the NLRP3 inflammasome at a concentration of 0.1 μM [1]. | |||
T9655 | NBC 6 | ||
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor with IC50 of 574 nM. NLRP3-IN-NBC6 acts independently of Ca 2+. NLRP3-IN-NBC6 inhibits Nigericin -induced inflammasome activation in THP-1 cells and Imiqu... | |||
T78639 | Oxidized ATP trisodium salt | oATP trisodium salt | P2X Receptor |
Oxidized ATP trisodium salt (oATP) is a broad-spectrum inhibitor of P2 receptors, irreversibly antagonizing P2X7R activation and inhibiting c-reactive protein (CRP)-induced NLRP3 inflammasome activation. It is utilized i... | |||
T69745 | GDC-2394 | ||
GDC-2394, an orally active, selective NLRP3 inhibitor, also targets IL-1β, exhibiting inhibitory concentrations (IC50s) of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). It effectively hampers NLRP3-induced caspase-1 act... | |||
T60356 | Stavudine sodium | ||
Stavudine sodium (d4T), an orally active nucleoside reverse transcriptase inhibitor (NRTI), demonstrates activity against both HIV-1 and HIV-2. It also inhibits mitochondrial DNA (mtDNA) replication, reduces NLRP3 inflam... | |||
T38106 | JC-171 | ||
JC-171, a selective inhibitor of the NLRP3 inflammasome, effectively inhibits LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages with an IC50 of 8.45 μM[1]. | |||
T81579 | P2X7 receptor antagonist-4 | ||
Compound 14a (P2X7 receptor antagonist-4) is a P2X7R antagonist with IC50 values of 64.7 nM in humans and 10.1 nM in mice. It inhibits the activation of the NLRP3 inflammasome, which subsequently reduces the expression o... | |||
T64281 | ODN TTAGGG | ||
ODN TTAGGG (A151) is an inhibitory oligonucleotide (ODN), a TLR9, AIM2 and cGAS antagonist. oDN TTAGGG competitively inhibits AIM2 inflammasome activation by DNA and inhibits cGAS activation, exhibiting immunosuppressive... | |||
T73337 | Articaine | Hoe-045 free base | |
Articaine (Hoe-045 free base), an amide anesthetic featuring an ester group, effectively relieves pain by reversibly binding to the α-subunit of the voltage-gated sodium channels located in the nerve's inner cavity. Furt... | |||
T37861 | Talabostat | ||
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 ... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T9352 | Hydrocotarnine | Others | |
hydrocotarnine is an inhibitor of Cbl. | |||
T6S1367 | Procyanidin B2 | Proanthocyanidin B2 | Reactive Oxygen Species , NOD |
Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression ... | |||
T3092 | Nigericin sodium salt | Potassium Channel , NOD-like Receptor (NLR) , Antibacterial , Antibiotic , NOD | |
Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-... | |||
TN1013 | Cucurbitacin D | Apoptosis | |
Cucurbitacin D, a triterpenoid isolated from Ecballium elaterium (L.), exhibits anticancer and antitumor activity, inhibits glucose uptake and lactate production in metastatic PrC, and induces inflammasome activation ind... | |||
T5716 | 4'-Methoxyresveratrol | 4'-O-Methylresveratrol | advanced glycation end products |
4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a natural product form the roots of Rheum palmatum L,has significant hypoglycemic, anti-inflammatory, and antioxidant effects.4'-Methoxyresveratrol alleviates AGE-induced... | |||
T72580 | Isoandrographolide | ||
Isoandrographolide, a compound known for its cell differentiation-inducing and hepatoprotective effects, also inhibits NLRP3 inflammasome activation and mitigates silicosis in mice. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPK-01228 | MARCO Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Macrophage receptor with collagenous structure (MARCO) is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). MARCO contributes to normal cholesterol uptake in... | |||
TMPH-02521 | PYCARD Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mit... | |||
TMPK-00161 | IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) | Human | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1... | |||
TMPK-00515 | IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1... | |||
TMPK-00162 | IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | E. coli |
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1... | |||
TMPJ-00789 | Flagellin Protein, Salmonella Typhimurium, Recombinant | Salmonella typhimurium | E. coli |
Flagellin is the major structural protein monomer of bacterial flagella. Flagellin through binding to its receptor and activation of antigen presenting cells stimulates the innate and adaptive immune responses. Flagellin... | |||
TMPY-01775 | AIM2 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
AIM2, Absent In Melanoma 2 is a member of the interferon-inducible HIN-200 protein family that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytopla... | |||
TMPH-01502 | Humanin Protein, Human, Recombinant (GST) | Human | E. coli |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e... | |||
TMPH-02671 | Gasdermin-D Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Precursor of a pore-forming protein that plays a key role in host defense against pathogen infection and danger signals. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-term... | |||
TMPH-01503 | Humanin Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective e... |